How to convert a comment to an issue

You can convert any comment in a design review to a new issue.

Click on the elipses "..." menu in the upper-right of any comment and select "Reference in new issue"

Type an issue name. You can edit the body text if you wish. Click "Create issue".

You can organize your issues with milestones. For example, if you are creating issues that need to be resolved before a design review is complete, you might create a milestone called "Merge blockers" and add it to the design review.